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The GPX3 gene is located on chromosome 5q33.1 and is composed of 6 exons that generate two alternatively spliced mRNAs that encode precursor proteins of 226 amino acids (isoform 1) and 235 amino acids (isoform 2)

USA 91 , 76087612 (1994)

Cell 175 , 85100.e23 (2018)

Cruciferous vegetables are preferred due to their high content of indole-3-carbonyl and sulforaphane, which powerfully enhance estrogen metabolism and detoxification (20)

Certain CYP isoformsnotably CYP2E1are potent sources of ROS, especially upon induction (e -TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Kyyriainen J, Kajevu N, Banuelos I, Lara L, Lipponen A, Balosso S, et al