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In rodent and pig models, pre-treatment of ischemic grafts with HOPE appeared able to counteract endothelial dysfunction, macrophage activation and improved mitochondrial metabolic pathways (149153)

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Phosphatidylcholine and cholesterol were dissolved in chloroform (40 mL) in a 1:1 molar ratio (125.2 mg phosphatidylcholine, 74.8 mg cholesterol) and treated as above

For intermediate-risk and high-risk patients, treatment with nelarabine was associated with a superior outcome (5-year DFS rate, 88.2% with nelarabine vs