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Collectively, these findings suggest that most animals obtain AX from their diet or have acquired the ability to convert it to AX through the acquisition of distinct and convergent oxidative metabolic functions during their evolution

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To compare the effects of paraxanthine against caffeine and the impact of age, young 8-week-old (YOUNG) and aged 16-month-old (OLD) rats were evenly divided into four groups ( n = 8 per group): (i) vehicle control (CON), (ii) low-dose paraxanthine (PXN LOW), (iii) high-dose paraxanthine (PXN HIGH), and (iv) high-dose caffeine (CAF HIGH)

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GSH homeostasis is further regulated by export, degradation, and regeneration