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The final goal is not just less pain
In mice, early engagement of the Notch and phosphatidylinositol 3-kinase (PI3K) signaling pathways, coupled with interleukin-7 (IL-7) signaling, promotes glycolysis and glutaminolysis in double-negative thymocytes (DN) (114)
When combining Bev with re-irradiation to treat recurrent GBM, She et al
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doi: 10.1038/s41591-018-0052-4
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