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Roumeliotis S, Roumeliotis A, Gorny X, Mertens PR (2020) Could antioxidant supplementation delay progression of cardiovascular disease in end-stage renal disease patients

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Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)

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The RAAS is over-activated, the ANG-II and aldosterone are increased under the hyperglycemic circumstance, which leads to the elevation of blood pressure and the destruction of sodium balance