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Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress. Cell Reports 30.7 (2020): 2430-2443.e4

Glutathione: pharmacological aspects and implications for clinical use

Despite promising preclinical data, targeting lipid peroxidation in clinical trials has not been successful [90], indicating that additional research exploring BBB penetrance of potential therapeutics and a better understanding of how lipid peroxides work in the temporal/biological context of TBI will be necessary before these metabolites can be harnessed for clinical benefit

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Metabolic Dysfunction Visceral fat (the fat surrounding organs), high blood sugar, and insulin resistance all release inflammatory molecules called adipokines, creating systemic inflammation
