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This affects every cell in the body but impacts high-energy-demand tissues like muscle, heart, and brain most severely

Recently, it has been shown that the plant GSH1 enzyme forms a homodimer linked by two redox-sensitive disulfide bonds (SS)

These findings highlight apigenins multifaceted role in overcoming drug resistance through interactions with drug efflux transporters and key signaling pathways

Current Neuropharmacology

[DOI] [PubMed] [Google Scholar] 143

Similarly, the mechanisms of toxicity proposed in some studies are different, including oxidative stress induction, physical membrane disruption or DNA damage