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B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review

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All experiments were approved by the Committee on the Use of Human and Animal Subjects in Teaching & Research at Hong Kong Baptist University (REC/1920/0296) and were performed in accordance with the Animals (Control of Experiments) Ordinance of the Department of Health, Hong Kong SAR, China

The pharmacological inhibitor of myoferlin can reduce the abundance of System X c - and GPX4 which trigger mitophagy and ROS accumulation culminating with lipid peroxidation and ferroptosis (Rademaker et al., 2022)

Furthermore, naringenin interferes with A plaque formation by regulating amyloid precursor protein (APP) processing, reducing A production, and preventing tau hyperphosphorylation, thereby safeguarding neurons from aggregationinduced toxicity (D'Egidio et al