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To date, eleven gene loci labeled PARK111, DJ-1, Parkin, leucine-rich repeat kinase 2 (LRRK2), ubiquitin carboxyterminal hydrolase-L1 (Uch-L1), -synuclein and PINK1 have been characterized according to their function and cellular localization (reviewed in [324, 325])

The researchers proposed that empagliflozin may activate the crucial enzyme for NAD+ synthesis, potentially restoring the tryptophan metabolic pathway in DKD [104]