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In a randomized controlled trial, participants were subjected to 12% calorie restriction, and their RNA sequences showed that up-regulated genes compared to controls were mainly enrichened in pathways such as autophagy, DNA repair, circadian rhythms, and mitochondrial biogenesis, whereas the inflammatory pathways were down-regulated

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Unlike the majority of transamination reactions, the enzyme catalyzing the formation of saccharopine does not employ pyridoxal phosphate as a cofactor

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