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In overdoses, symptom onset can be as soon as 3 hours and the average time to death was 14 hours

doi: 10.1016/j.tim.2015.02.005

& Burnstock, G

Mitchell A et al (2005): Clonidine lowers blood pressure by reducing vascular resistance and cardiac output in young, healthy males

Besse-Patin et al report that PGC1A promotes ER expression while also acting as an ER coactivator to mediate an antioxidant response involving increased expression of antioxidant genes such as superoxide dismutase 2 and glutathione peroxidase-1 (84)

There is also a higher proportion of candidates in clinical development, as opposed to discovery and preclinical, (65% vs