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If treatment is requested the macules can be frozen (cryotherapy) or removed using a laser or intense pulsed light

The models mentioned above may also help develop new therapeutic approaches to treat or prevent the occurrence of AR-negative prostate cancer (Fig

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Interestingly, the pentamer changes into the monomeric form after interacting with activated membranes through a procedure involving an intermediate CRP form known as monomeric CRP m or pentameric CRP*, a form which represents the initial stages of subunit dissociation, in which the still-pentameric protein begins expressing antigenic and functional attributes, which are characteristic of monomeric CRP [68]