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Description

Other symptoms include fatigue [3], sleep disturbances [4], cognitive issues [5], mood disorders [6], sensory impairments [7], gastrointestinal disorders [8], morning stiffness [9], dizziness [10], restless legs syndrome (RLS) [11], and painful menstrual periods (known as dysmenorrhea) [12]

It is not appropriate for everyone, and understanding who benefits most helps researchers make informed decisions about whether the added complexity and cost are justified

TWAS is a two-stage framework that first trains a model to predict gene expression levels from genetic variation, thereby estimating the genetically regulated component of expression, and then tests for association between imputed expression and the trait of interest

Vegans, vegetarians, people over the age 50, anyone with stomach/bowel issues like chronic gastritis, leaky gut, IBS or celiac, and anyone who regularly takes medications such as Metformin, PPIs (used for GERD), H2 Receptor Antagonists (used for peptic ulcers), or anything that interferes with stomach acid production are actually at risk for vitamin B12 deficiency, and should supplement B12 regularly