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Additionally, electrophysiological experiments have shown the direct effects of B vitamins on pain transmission pathways in the spinal cord and thalamus, which explains the observed reduction or loss of pain sensation in clinical patients

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"These just kind of make you feel, you know, sprucy all day," said Bloomstadt

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B12 also downregulated CSF2 ( P = 0.0071) and CXCL10 ( P = 0.0205) in leukocytes from impaired individuals, although these genes were not differentially regulated when compared to the non-impaired group

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