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Description
Complex I catalyzes the oxidation of reduced NADH and the reduction of ubiquinone with the contribution of two electrons and four protons, promoting the formation of a proton gradient across the IMM [35]
Recent Mendelian randomization findings further validate this framework: Dorea and Sellimonas appear protective, whereas Phascolarctobacterium and Ruminococcaceae UCG-004 are associated with increased PTSD risk (O'Hare et al., 2024
Therefore, we are also soliciting comment on additional measures to consider for incorporation in the designation for future years
Among these, accumulation of p62, also known as sequestosome 1 (SQSTM-1) and A170 (119), sequesters Keap1 into aggregates, resulting in the inhibition of Keap1-mediated Nrf2 ubiquitination and its subsequent degradation by the proteasome (120)
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Blood-Brain Barrier: From Physiology to Disease and Back
