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B12 is essential for red blood cell formation, neurological function, and DNA synthesis

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Similar results were demonstrated in vitro with C2C12 cells that closely mimic muSCs, where NNMTi treatment promoted myoblast differentiation and supported metabolic changes in NAD+ salvage pathway-related cellular metabolites[5]

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Given the safety, relative low cost, and significant affect cobalamin deficiency can have on quality of life, we recommend B12 supplementation for all emaciated patients, regardless of whether access to serum cobalamin testing is available