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Key points Endocrine-disrupting chemicals of various sources, classifications and mechanisms of actions might promote prostate cancer development

However, none of these hypotheses alone can fully explain the pathological basis of MDD, while many mechanisms proposed by these hypotheses interact with each other

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The Bcl-2 family, in contrast, includes Bcl-2, which can protect cells from various apoptotic triggers, and Bax, an apoptosis agonist that acts through heterodimerisation with Bcl-2 [43]

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