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WormBook 114 (2005)

One example is cancer cells, which shift the balance too far off to the methylation side of the cycle

In particular, macrophages express scavenger receptors and gluttonously take up large quantities oxLDL to form foam cells in the initial atherosclerotic lesion (301)

Regulation of Cholesterol Homeostasis Although some cholesterol is converted to oxysterols and bile acids, it cannot be catabolized for energy purposes (see below), and its synthesis must be tightly regulated as it so expensive energetically

The CACT transporter is a member of the SLC family of transporters and as such is encoded by the SLC25A20 gene

Non-hepatic ketone body utilization occurs via a series of mitochondrial reactions (shown in the Figure below) that are essentially a reversal of ketone body synthesis