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For some, a single injection can provide benefits for a week or two

Megalencephalic leukoencephalopathy with subcortical cysts (MLC), is another primary leukodystrophy caused by recessive pathogenesis variants in the genes MLC1 (Modulator of VRAC Current 1) or HEPACAM (Hepatic and Glial Cell Adhesion Molecule, previously known as GlialCAM ) 338

To view a copy of this licence, visit About this article Cite this article Lee, J., An, S., Kim, Y.W

The authors report no other conflicts of interest in this work

While such optimizations to trial design may succeed in gaining approval for additional immunosuppressive therapies, allowing pharmaceutical companies to claim their share of the insurance market, they do nothing to genuinely benefit patients with UC and instead contribute to escalating healthcare costs