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Compared with traditional therapy modalities, nanoparticles improve the targeting efficiency of mitochondria, enhance the stability and bioavailability of therapeutics, and reduce the side effects on other non-target sites

[DOI] [PMC free article] [PubMed] [Google Scholar] 492.Woolley D.W

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Using an ex vivo murine model of myocardial ischemia/reperfusion injury, it was found that IGF-1 protects ischemic myocardium from further reperfusion injury, likely via maintenance of mitochondrial to nuclear DNA ratio within heart tissue [81] and by activation of the PI3K-Akt and/or Erk 1/2 kinase cascades [82]

PMC 7407102

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