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Additional pathway specific studies in GBM cell lines have shown that radiation induces a transition in metabolic preference from glycolysis to oxidative phosphorylation via mTOR mediated HEK2 inhibition (Zhou and Wahl, 2019)

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In humans, glutamine is synthesized from glutamic acid and this conversion step is vitally important in regulating the level of toxic ammonia in the body, forming urea and purines