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The official prescribing information does mention depression under the Postmarketing Experience listing

Older adults: Absorption efficiency decreases with age

However, many people may be deficient in this vitamin due to various factors such as age, diet, or certain medical conditions

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Validated assay content of 10.26 mg Purity greater than 99.8 percent Retention time and spectral identity confirmation Endotoxin levels below 0.001 EU per mg No detectable microbial contamination No detectable heavy metals High purity research compound for controlled laboratory experiments Supplied in sealed sterile research vial For research use only not for human or veterinary use For laboratory research only

[9] If you do feel flush or itchy, it should be mild and short-lived