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In the immune system, expression of a plethora of iGluRs and mGluRs in human T cells has been reported in resting and activated cells and under normal and cancer conditions (210, 211)

10.1186/s12974-023-02776-z 71 LiuT

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Notably, currently available therapies for RA, such as cytokine (TNF and IL-6) blockers or inhibitors of the JAK-STAT pathway 43 , exclusively tackle the inflammatory phase of the disease but do not interfere with the underlying processes that initiate the onset of arthritis and therefore often need to be given life-long 44