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The treatment with OSMI-1 and Azaserine demonstrated a non-significant reduction of O-GlcNAcylated proteins, because their formation depends on the availability of UDP-GlcNAc as a substrate ( An increase in global O-GlcNAcylation levels was observed when J774 cells were treated with TMG, for 8 and 12 h (Figure 2)

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Neurobiol Aging (2013) 34(7):e17.10.1016/j.neurobiolaging.2013.01.003 24 MentleinRRoosT