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Expression and secretion of GAL3 by macrophages is thought to play a role in the activation of renal fibroblasts to its profibrotic prototype 53 , and elevated plasma GAL3 is associated with major adverse kidney events and death 54

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However, the shorter treatment time for conditioning (typically between 12 weeks before transplant), compared to immunotherapy as a disease treatment, may circumvent these issues that are seen in longer-term treatment strategies

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Lim EJ, Hong DY, Park JH, Joung YH, Darvin P, Kim SY, et al

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