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Proc Natl Acad Sci USA 101: 66756680, 2004
Supplementation is most effective when it is consistent, rather than intense
Neutrophils contain an extensive antimicrobial arsenal that includes a) Pentraxin 3 contained in specific granules and neutrophil extracellular traps, b) elastase (a component of azurophil granules), and c) nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase
Glutamine, a non-essential amino acid, seems to be strongly present in this communication
Moreover, it negatively regulates the accessibility and infiltration of immune cells by affecting the metabolite availability for immune effector cells and by inducing an immunosuppressive phenotype via an upregulation of immune checkpoints on cancer cells, e.g., PD-L1 [11, 12]
