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Addition of R-lipoic acid increases ATP synthesis and aortic blood flow during reoxygenation after hypoxia while S-lipoic acid had no effect on ATP synthesis and improved blood flow at only 10-fold the effective dose of R-lipoic

Clinical studies have shown that ALA significantly improves neuropathic symptoms and nerve conduction velocities

The problem with carnitine Muscle takes up carnitine against a very large (about 1,000-fold) concentration gradient (plasma carnitine is 40-60 mol/L and muscle carnitine is 4-5 mmol/L)

This form of carnitine is crucial for transporting long-chain fatty acids into the mitochondria, where they are oxidised to produce energy

This means that they both cannot be made within the body and must be consumed in the diet

Supports exercise performance and endurance