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Biotechnology and Bioengineering, 89(6): 670679 Zhang Y, Guo Y, Fang J, Guo K, Yu G, Wang Y (2023)

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Unlike other TGF- superfamily proteins, the mature C-terminal domains of GDF8 and GDF11 remain tightly bound to their prodomains even after Furin cleavage and require TLD cleavage of the prodomain to convert from an inactive to a triggered state that is primed for subsequent activity of the mature, signaling-competent ligand [73-75]

These benefits appear to be related, in part, to enhanced recruitment of collateral circulation, which supports oxygen delivery to compromised cardiac tissue