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Cancer 8 , 967975 (2008)

Glutathione synthesis in cancer cells is largely dependent on cysteine, a precursor derived from cysteine, which is transported into the cell via the xCT (SLC7A11) transporter 14

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Full geometry optimizations, relaxed scans and transition structure searches were carried out with Gaussian 16 83 with the ONIOM 84 QM/MM method using the B3LYP hybrid functional 85 and 6-31 G(d) basis set with ultrafine integration grids for the QM part and the ff14SB 78 , gaff2 79 and TIP3P 86 force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

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