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This enhanced penetration translates to significant in vivo efficacy, with RGD-modified nanoparticles reducing tumor volumes to 354.6 mm, representing a 55% reduction compared to the free drug group (781.4 mm) and a 71% reduction compared to the saline control group after 27 days treatment, attributed to curcumins ability to downregulate fibrosis-associated proteins and inhibit cancer-associated fibroblasts

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