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Plasma will be assessed pre- and post-treatment (baseline and three months) as well as every three months during the 9-month no-treatment follow-up period

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After 8 weeks, the treatment group showed a 20% increase in hydration levels, measured by corneometry, and improved epidermal and dermal thickness due to enhanced glycosaminoglycan synthesis (Krger et al., 2010)

Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation