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HadadiAOstovarAEdalat NoorBRasoolinejadMHaji AbdolbaghiMYousefiSet al

Dystonia, which was previously classified as a disease of basal ganglia, is now regarded as a network disorder that includes other extrapyramidal structures like the cerebellum

The pain from the nerve damage can be severe with tingling or numbness in the part of the body
The body must convert it back to GSH for biological activity

This triad of hippocampal impairment, limbic hyperexcitability, and prefrontal disinhibition constitutes a core pathological circuit remodeled in chronic pain and mood disorders, highlighting the interplay between structural plasticity and functional network dyssynchrony

Clock-controlled output genes modulate a myriad of metabolic and cellular functions, such as the regulation of energy balance, DNA-damage repair and xenobiotic detoxification in both mammals [9][11] and Drosophila [12][14]
