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An expanded access protocol of RT001 in amyotrophic lateral sclerosis-Initial experience with a lipid peroxidation inhibitor

Each component represents a distinct structural class of peptide.nnGHK-Cu is a copper-bound tripeptide first isolated from human plasma in 1973.nnBPC-157 is a synthetic 15-amino-acid peptide derived from a partial sequence of a protein found in human gastric juice.nnTB-500 is a synthetic peptide based on the Thymosin Beta-4 sequence, a 43-amino-acid polypeptide naturally expressed in many human tissues.nnGLOW is studied in preclinical experiments examining collagen synthesis, extracellular matrix remodelling, angiogenic activity, and tissue-repair processes, with each peptide contributing to a different stage of the regenerative cycle

Alpha-Lipoic Acid Alpha-lipoic acid also contains thiol groups and has been shown to protect the cochlea from cisplatin-induced ototoxicity and noise in animal models [74,76]

The studies were approved by the University of Pittsburgh Institutional Review Board (IMSA, PRO15050456

As shown in Figure 3C, the CFS of L

& Tooze, S