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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Westphal J, Vetter D, Brogard J

Research confirms that Pycnogenol enhances endothelial NO production by increasing endothelial nitric oxide synthase (eNOS) activity and protects the generated NO from degradation by scavenging superoxide anion radicals, thereby improving its bioavailability (250)

Improved blood circulation

For instance, in rats portal vein concentrations reached 2.5 M and liver concentrations 147 M after oral gavage of 50 mg/kg phenformin 69

demonstrated that mice given oral glutathione showed increased concentrations in kidney, heart, lung, brain, and small intestine within one hour

Mechanical allodynia assessment Von Frey testing was conducted using an ascendingdescending protocol 47