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reported that treatment with daratumumab increases MM cell death, especially in the presence of a subset of CD14 + /CD16 + monocytes, and that combining daratumumab with anti-CD47 enhances the elimination of MM cells that are resistant to daratumumab alone (66)

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Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway