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In particular, during glucose starvation or severe energy crises such as mitochondrial dysfunction, AMPK has been shown to negatively regulate ULK1 activity, either by inhibiting ULK1-dependent autophagosome formation or by disrupting lysosomal acidification, thereby attenuating autophagy initiation

33 , 21742188.e5 (2021)

Feb 11 2016

It is well known that postmenopausal women exhibit physiological alterations including weight gain, changes in adipose tissue distribution, and deterioration of insulin secretion, and sensitivity [4, 5]

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The authors concluded that prolonged increases in vein wall tension are associated with overexpression of HIF-1 and HIF-2 , increased MMP-2 and MMP-9 expression, and reduced venous contraction in rat IVC