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Nutrient experts such as Dr Bodo Kuklinski therefore recommend taking biotin as part of a vitamin B12 therapy: Vitamin B12 has no effect without an accompanying biotin intake [] Under vitamin B12 therapy, the need for biotin increases, and if not supplemented, skin problems, brittle hair and nails as well as spots occur

For diabetic patients taking metformin, a combination of B12 and calcium supplements are therefore useful

For B12 to be absorbed properly, your stomach produces intrinsic factor, a protein essential for uptake

It is recommended to follow up these patients closely to understand the natural history to develop better recommendations for management

When you get an injection, the vitamin goes straight into your bloodstream and gets stored in your liver for future use

Shi, J.-R., Santer, B