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Standardization of Senescence Biomarkers: A major challenge in both the development and application of senescence-targeting therapies is the identification of reliable biomarkers that can accurately assess the presence of senescent cells and their effects.256 Current biomarkers for senescence, such as p16^INK4a, -galactosidase activity, and SASP factors, are useful in research settings, but their clinical applicability remains limited

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Across in vitro and preclinical models, GHK-Cu has been studied for its influence on gene expression programs related to matrix synthesis and remodeling, antioxidant defenses, and pathways associated with cellular senescence markers

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