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2.2 Entry of ascorbate into brain cells Once in the CSF, ascorbate appears to enter the brain interstitium by diffusion, since interstitial brain ascorbate concentrations of 200-400 M are similar to or only slightly higher than those in the CSF [53,54]

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After this acute phase is over and host CD4+ memory T cells undergo a temporary phase of regeneration, patients with HIV experience another progressive decline in CD4+ T cell counts

Frequent infections: These can also be symptoms of a vitamin B12 deficiency and may be accompanied by lightheadedness