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Several recent studies have shown that 4-PSQ reversed OXA-induced mechanical and thermal hypersensitivity, ameliorated chemotherapy-induced oxidative imbalance by reducing reactive species (RS) levels, normalizing glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) and acetylcholinesterase (AChE) activities in all tissues [161], and reversed aging-aggravated by reducing ROS and NOx levels [162]

Older patients are more likely to be affected than younger patients [72]

It is also known that under certain conditions, ASA can bind with iron [229,230], even though no literature describes this in vivo (Figure 2)

A study by Adham et al

However, critical gaps persist: many underdeveloped regions lack robust surveillance, nonmotor symptoms remained underreported, and sexdisaggregated data show inconsistencies [40, 41, 52, 56]

doi: 10.1016/0009-2797(93)90082-A