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He was a phamacologist who helped develop the chemical treatment of cancer

Although Snitrosylation targets only certain Cys residues, this selectivity can be partially abolished by transnitrosylation, during which a low-molecular-weight nitrosothiol (e.g., GSNO) or a protein nitrosylated at Cys residue or bearing a nitrosylated metal ion (e.g., in the heme) can interact with a protein undergoing Snitrosylation and transfer nitroso group (ON-) to the Cys residue of this protein: PrS + PrSNO PrSNO + PrS , PrS + MeSNO PrSNO + Me

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Similarly, treatment with AC markedly halted DU-145 and PC-3 prostate cancer cell proliferation and migration by downregulating the HMGB1/receptor for advanced glycation end products (RAGE) signaling cascade and its downstream transforming growth factor-beta I/II (TGF-I/II)/SMAD family member 2/3 (Smad2/3) pathway

Despite limited studies in recent years, enhancing T cell metabolism holds significant promise for treating liver cancer, particularly when combined with immune checkpoint inhibitors