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Biochem Biophys Res Commun (2019) 515:44854

B 5 (4), 285299

Rights and permissions About this article Cite this article Beloucif, A., Kechrid, Z

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Various animal models of atherosclerosis, encompassing species such as mice, rabbits, and primates, have similarly revealed that hypercholesterolemia induces significant modifications in endothelium-dependent vasodilation [19,20,82]

In this context, the present work evaluated the applicability of the commercially available upper MucilAir-HF and lower EpiAlveolar human lung models to be used as in vitro systems within a NAM toolbox to identify the bioactivity (i.e., in vitro PoD derivation) and risk of materials that may reach the respiratory tract and induce lung toxicity