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This selfsustaining state of central hyperexcitability, capable of outlasting the initial peripheral trigger, forms a key pathophysiological basis for a wide spectrum of chronic pain conditions [62]

It has the additional advantage that it is not limited by a substrate

He documented his progression over more than a month while also tracking: hydration, headache response, blood pressure observations, and injection-site changes

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Most people feel only a small pinch

This was followed by derivatization using acetaldehyde nitrile acetate, after which GC-MS analysis was performed