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These findings reveal that the therapeutic benefit of PD1/PD-L1 blockade is highly dependent on preexisting T-cell infiltration, a finding that was subsequently confirmed to be a common basis for the responses to various immunotherapies, such as CTLA-4 blockade and ICT treatment [106]

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The true diagnosis is an autonomic dysregulation of the Parasympathetic nervous system causing GI track dysmotility upper and lower