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Both caloric restriction and KD decrease inflammatory and pro-apoptotic activities through activation of PPAR (125, 126)

These enzymes represent the most extensively studied target genes of the AhR/ARNT complex of the activation of the classic pathway of AhR

Seemingly, KYNA (and its 7-chloro derivative) can also be effluxed by MRCP4 (ABCC4) as well as by SLC22A6/8 [242,244], as each of these transporters is inhibited by probenecid, whose presence led to an 885-fold increase in the concentration of 7-Cl-KYNA in the prefrontal cortex of rats [242] (see also [240,245,246,247,248,249,250])

Successful adoption will require context-specific packages that distinguish grain vs leafy types, rainfed vs irrigated systems, and smallholder vs mechanized farms (Kaur et al., 2024

Bioanalysis 8(18):190317 Gostner JM et al (2020) Tryptophan metabolism and related pathways in psychoneuroimmunology: The Impact of Nutrition and Lifestyle

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