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In A, the linear sequence of amino acids 2235 is a functional cholesterol-binding domain that is unusual in that it does not contain the aromatic residues common in other cholesterol-binding protein domains
Cordero, M

at the time, Jacob Senden was rushed to the hospital and told he had two hours to live

doi: 10.4049/jimmunol.1002315

While these findings provide biological plausibility for a direct cardiac mechanism, they do not demonstrate functional receptor activity or confirm that semaglutide acts directly on these cells