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Requirements for vitamin C increase during infection

Reports of stability in gastric juice are not the same as systemic bioavailability, and routes of administration in published rodent work include intraperitoneal, oral (drinking water), and topical comparisons across routes are not always controlled in primary studies (Cerovecki et al., 2010)

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Under pathological conditions, disruption of TFAM can lead to mtDNA mispackaging, a massive release of damaged mtDNA, and down-regulation of TFAM also reduces the stability of the mtDNA mimetic nuclear structure (West et al., 2015)