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Always talk to a knowledgeable and experienced healthcare provider before beginning any treatments for weight loss

In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

The vitamin B 12 supplementation study in pregnancy from South India 24 and the study from Bangladesh 26 used very high doses of 20100 RDA with no reported adverse effects
Most people following a varied diet get the recommended amount, but vegans, people with certain gut conditions and older adults who absorb nutrients less efficiently may need supplements

Insurance may cover them for medical issues like B12 deficiency but not for weight loss or energy purposes
