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Source of Acetyl-CoA and NADPH Acetyl-CoA, required for fatty acid synthesis, is generated in the mitochondria but must be transported to the cytosol: Acetyl-CoA combines with oxaloacetate to form citrate Citrate is transported to the cytosol ATP-citrate lyase releases acetyl-CoA in the cytosol NADPH , the reducing agent for fatty acid synthesis, is supplied by: Pentose phosphate pathway Malic enzyme reaction Both acetyl-CoA and NADPH are essential substrates in lipid biosynthesis

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