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doi: 10.1007/s00401-007-0220-y 24 KoeppenA

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When administered in higher doses through injections, it is believed to reduce melanin production, leading to lighter skin tone over time

[DOI] [Google Scholar] 11.Dimidi E., Cox S., Rossi M., Whelan K

Indeed, BH4 has emerged as a critical regulator of redox homeostasis in macrophages, where loss of GCH1 promotes the accumulation of iNOS-dependent and -independent ROS and impairs NRF2 activation [216]

The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2